FKBP1B

FKBP1B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase, FK506 binding protein 1B
External IDs MGI: 1336205 HomoloGene: 68380 GeneCards: FKBP1B
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

2281

14226

Ensembl

ENSG00000119782

ENSMUSG00000020635

UniProt

P68106

Q9Z2I2

RefSeq (mRNA)

NM_004116
NM_054033
NM_001322963
NM_001322964

NM_016863

RefSeq (protein)

NP_004107.1
NP_473374.1

NP_058559.3

Location (UCSC) Chr 2: 24.05 – 24.06 Mb Chr 12: 4.83 – 4.84 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.[3][4]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Arakawa H, Nagase H, Hayashi N, Fujiwara T, Ogawa M, Shin S, Nakamura Y (Jun 1994). "Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts". Biochem Biophys Res Commun. 200 (2): 836–43. doi:10.1006/bbrc.1994.1527. PMID 7513996.
  4. 1 2 "Entrez Gene: FKBP1B FK506 binding protein 1B, 12.6 kDa".

Further reading


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