Edward O'Brien
Edward O'Brien may refer to:
- Edward Joseph Harrington O'Brien (1890–1941), American author
- Edward O'Brien (Irish republican) (1974–1996), IRA member
- Edward O'Brien, 14th Baron Inchiquin (1839–1900), Irish peer
- Sir Edward O'Brien, 2nd Baronet (1705–1765), Irish politician and baronet
- Sir Edward O'Brien, 4th Baronet (1773–1837), Irish politician and baronet
- Edward O'Brien (athlete) (1914–1976), American 400m runner
- Eddie O'Brien (baseball) (1930–2014), American former Major League Baseball player
- Eddie O'Brien (hurler) (born 1945), retired Irish hurler
See also
- Ed O'Brien (born 1968), guitarist for Radiohead
- Edward O'Bryen (c. 1753–1808), (sometimes O'Brien), Royal Navy admiral
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