Echinopsidine

Echinopsidine
Skeletal formula of echinopsidine
Clinical data
Routes of
administration
Oral
ATC code none
Legal status
Legal status
  • ℞ (Prescription only)
Identifiers
Synonyms Echinopsidine Iodide
CAS Number 2400-75-1
58916-73-7 (hydroiodide)
PubChem (CID) 161462
ChemSpider 141825
Chemical and physical data
Formula C10H12N2
Molar mass 160.22 g/mol

Echinopsidine (Adepren) is an antidepressant that was under development in Bulgaria for the treatment of depression.[1][2] It increases serotonin, norepinephrine, and dopamine levels in the brain and is believed to act as a monoamine oxidase inhibitor (MAOI).[3][4][5] Echinopsidine is found naturally in Echinops echinatus along with the related alkaloids echinopsine and echinozolinone.[6]

See also

References

  1. Guliamov MG (1982). "[Experience with the use of new Bulgarian psychotropic drugs]". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952) (in Russian). 82 (11): 115–22. PMID 6758442.
  2. Guliamov MG (1986). "[Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit]". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952) (in Russian). 86 (4): 582–7. PMID 3716711.
  3. Tiutiulkova N; Gorancheva Iu (1978). "[Effect of adepren on the cerebral concentration of serotonin]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian). 17 (2): 83–5. PMID 658004.
  4. Stefanova D, Tiutiulkova N, Nikolova M (1976). "[Effect of adepren on the behavior and brain catecholamines of rats in an open field setup]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian). 15 (1): 42–6. PMID 1269462.
  5. Tiutiulkova NI; Gorancheva IuI (1975). "[Excretion of dopamine, noradrenaline, adrenaline, vanilmandelic acid and 5-hydroxyindoleacetic acid in the urine of volunteers treated with adepren]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian). 14 (4): 187–9. PMID 1222713.
  6. Indian Medicinal Plants An Illustrated Dictionary. Springer-Verlag Berlin Heidelberg. 2007. ISBN 0-387-70637-2.


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