ETV6-NTRK3 gene fusion

ETV6-NTRK3 gene fusion is the translocation of genetic material between chromosomes 12 and 15 (t(12;15)). This creates a new gene in which the 5' region of ETV6 is fused to the 3' region of NTRK3.^[1] The resulting transcript encodes and chimeric oncoprotein consisting of the helix-loop-helix (HLH) protein dimerization domain of ETV6 fused to the protein tyrosine kinase (PTK) domain of NTRK3.^[2]

The ETV6-NTRK3 gene fusion was originally identified in congenital fibrosarcoma ^[1] but has since been identified in secretory breast carcinoma^[3] and its correlate in the salivary gland, mammary analogue secretory carcinoma.^[4]

NTRK3 Inhibitors in Clinical Development

Entrectinib is a pan-NTRK, ALK, and ROS1 tyrosine kinase inhibitor in phase 2 clinical development.

References

1. 1 2 Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (18 Feb 1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma". Nat Genet. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753. 
2. ↑ Wai DH, Knezevich SR, Lucas T, Jansen B, Kay RJ, Sorensen PH (Feb 17, 2000). "The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells". Oncogene. 19 (19(7)): 906–15. doi:10.1038/sj.onc.1203396. PMID 10702799. 
3. ↑ Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers JA, Becker L, Carneiro F, MacPherson N, Horsman D, Poremba C, Sorensen PH (Nov 2002). "Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma". Cancer Cell. 2 (5): 367–76. doi:10.1016/S1535-6108(02)00180-0. PMID 12450792. 
4. ↑ Majewska H, Skálová A, Stodulski D, Klimková A, Steiner P, Stankiewicz C, Biernat W. "Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement." Virchows Arch. 2015 Mar;466(3):245-54. doi: 10.1007/s00428-014-1701-8. Epub 2014 Dec 12.