Dipeptidase E

Dipeptidase E
Identifiers
EC number 3.4.13.21
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Dipeptidase E (EC 3.4.13.21, aspartyl dipeptidase, peptidase E, PepE gene product (Salmonella typhimurium)) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Dipeptidase E catalyses the hydrolysis of dipeptides Asp!Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides

A free carboxy group is not absolutely required in the substrate.

References

  1. Haakansson, K.; Wang, A.H.J.; Miller, C.G. (2000). "The structure of aspartyl dipeptidase reveals a unique fold with a Ser-His-Glu catalytic triad". Proc. Natl. Acad. Sci. USA. 97 (26): 14097–14102. doi:10.1073/pnas.260376797. PMID 11106384.
  2. Lassy, R.A.L.; Miller, C.G. (2000). "Peptidase E, a peptidase specific for N-terminal aspartic dipeptides, is a serine hydrolase". J. Bacteriol. 182 (9): 2536–2543. doi:10.1128/jb.182.9.2536-2543.2000. PMID 10762256.

External links

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