Diminazen
Clinical data | |
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Trade names | Azidin, Berenil, Ganasag, Pirocide |
Routes of administration | IM, SC |
ATCvet code | QP51AF01 (WHO) QP51AX07 (WHO) |
Legal status | |
Legal status |
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Identifiers | |
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Synonyms | 4,4'-(1-Triazene-1,3-diyl)bis(benzenecarboximidamide) |
CAS Number |
536-71-0 aceturate: 908-54-3 |
PubChem (CID) | 2354 |
ChemSpider | 2264 |
UNII |
Y5G36EEA5Z aceturate: JI8SAD85NO |
ChEBI | CHEBI:81724 |
ChEMBL | CHEMBL124025 |
ECHA InfoCard | 100.007.860 |
Chemical and physical data | |
Formula | C14H15N7 |
Molar mass | 281.316 g/mol |
3D model (Jmol) | Interactive image |
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Diminazen(e) is an anti-infective medication for animals that is sold under a variety of brand names (see drugbox). It is effective against certain protozoa such as Babesia, Trypanosoma and Cytauxzoon. The drug may also be effective against certain bacteria including Brucella and Streptococcus.[1][2]
Chemically it is a di-amidine, and it is used in form of the aceturate (N-acetylglycinate).
The mechanism is not well understood; it probably inhibits DNA replication,[1] but also has affinity to RNA.
Side effects
Acute side effects include vomiting, diarrhoea and hypotension (low blood pressure). Diminazen can harm the liver, kidneys and brain, which is potentially life-threatening; especially camels are susceptible to these effects.[1]
References
- 1 2 3 Peregrine, A. S.; Mamman, M. (1993). "Pharmacology of diminazene: A review". Acta tropica. 54 (3–4): 185–203. doi:10.1016/0001-706X(93)90092-P. PMID 7902657.
- ↑ Mungube, E. O.; Vitouley, H. S.; Allegye-Cudjoe, E.; Diall, O.; Boucoum, Z.; Diarra, B.; Sanogo, Y.; Randolph, T.; Bauer, B.; Zessin, K. H.; Clausen, P. H. (2012). "Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali". Parasites & Vectors. 5: 155. doi:10.1186/1756-3305-5-155. PMC 3432589. PMID 22852796.
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