Diminazen

Diminazen
Ball-and-stick model of diminazen
Clinical data
Trade names Azidin, Berenil, Ganasag, Pirocide
Routes of
administration
IM, SC
ATCvet code QP51AF01 (WHO) QP51AX07 (WHO)
Legal status
Legal status
  • Veterinary
Identifiers
Synonyms 4,4'-(1-Triazene-1,3-diyl)bis(benzenecarboximidamide)
CAS Number 536-71-0
aceturate: 908-54-3
PubChem (CID) 2354
ChemSpider 2264
UNII Y5G36EEA5Z YesY
aceturate: JI8SAD85NO
ChEBI CHEBI:81724 YesY
ChEMBL CHEMBL124025 YesY
ECHA InfoCard 100.007.860
Chemical and physical data
Formula C14H15N7
Molar mass 281.316 g/mol
3D model (Jmol) Interactive image

Diminazen(e) is an anti-infective medication for animals that is sold under a variety of brand names (see drugbox). It is effective against certain protozoa such as Babesia, Trypanosoma and Cytauxzoon. The drug may also be effective against certain bacteria including Brucella and Streptococcus.[1][2]

Chemically it is a di-amidine, and it is used in form of the aceturate (N-acetylglycinate).

The mechanism is not well understood; it probably inhibits DNA replication,[1] but also has affinity to RNA.

Side effects

Acute side effects include vomiting, diarrhoea and hypotension (low blood pressure). Diminazen can harm the liver, kidneys and brain, which is potentially life-threatening; especially camels are susceptible to these effects.[1]

References

  1. 1 2 3 Peregrine, A. S.; Mamman, M. (1993). "Pharmacology of diminazene: A review". Acta tropica. 54 (3–4): 185–203. doi:10.1016/0001-706X(93)90092-P. PMID 7902657.
  2. Mungube, E. O.; Vitouley, H. S.; Allegye-Cudjoe, E.; Diall, O.; Boucoum, Z.; Diarra, B.; Sanogo, Y.; Randolph, T.; Bauer, B.; Zessin, K. H.; Clausen, P. H. (2012). "Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali". Parasites & Vectors. 5: 155. doi:10.1186/1756-3305-5-155. PMC 3432589Freely accessible. PMID 22852796.


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