DRG1

DRG1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2EKI

Identifiers

DRG1, NEDD3, developmentally regulated GTP binding protein 1

External IDs

MGI: 1343297 HomoloGene: 3060 GeneCards: DRG1

Gene ontology
Molecular function	• nucleotide binding • GTP binding • transcription factor binding • protein binding • identical protein binding
Cellular component	• cytoplasm • polysome • membrane
Biological process	• multicellular organism development • transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


4733


13494


ENSG00000185721


ENSMUSG00000020457


Q9Y295


P32233

RefSeq (mRNA)


NM_004147


NM_007879

RefSeq (protein)


NP_004138.1


NP_031905.1

Location (UCSC)

Chr 22: 31.4 – 31.53 Mb

Chr 11: 3.19 – 3.27 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Developmentally-regulated GTP-binding protein 1 is a protein that in humans is encoded by the DRG1 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. PMID 7929244.
↑ Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem Biophys Res Commun. 189 (1): 363–70. doi:10.1016/0006-291X(92)91567-A. PMID 1449490.
↑ "Entrez Gene: DRG1 developmentally regulated GTP binding protein 1".

Further reading

Sazuka T, Kinoshita M, Tomooka Y, et al. (1992). "Expression of DRG during murine embryonic development.". Biochem. Biophys. Res. Commun. 189 (1): 371–7. doi:10.1016/0006-291X(92)91568-B. PMID 1280421.
Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins.". Oncogene. 12 (11): 2343–50. PMID 8649774.
Zhao XF, Aplan PD (1999). "SCL binds the human homologue of DRG in vivo.". Biochim. Biophys. Acta. 1448 (1): 109–14. doi:10.1016/s0167-4889(98)00129-3. PMID 9824680.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins.". Biochim. Biophys. Acta. 1491 (1–3): 196–204. doi:10.1016/s0167-4781(00)00025-7. PMID 10760581.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bandyopadhyay S, Pai SK, Gross SC, et al. (2003). "The Drg-1 gene suppresses tumor metastasis in prostate cancer". Cancer Res. 63 (8): 1731–6. PMID 12702552.
Bandyopadhyay S, Pai SK, Hirota S, et al. (2004). "Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression". Oncogene. 23 (33): 5675–81. doi:10.1038/sj.onc.1207734. PMID 15184886.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Bandyopadhyay S, Wang Y, Zhan R, et al. (2007). "The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer". Cancer Res. 66 (24): 11983–90. doi:10.1158/0008-5472.CAN-06-0943. PMID 17178897.

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