DDO (gene)

DDO
Identifiers
Aliases	DDO, Ddo, 5330420D20Rik, 5730402C02Rik, AI467244, DASOX, DDO-1, DDO-2, D-aspartate oxidase
External IDs	MGI: 1925528 HomoloGene: 101531 GeneCards: DDO
Gene ontology Molecular function • oxidoreductase activity • FAD binding • receptor binding • protein binding • D-amino-acid oxidase activity • cofactor binding • D-aspartate oxidase activity Cellular component • peroxisome • peroxisomal matrix Biological process • insemination • grooming behavior • aspartate metabolic process • D-amino acid metabolic process • hormone metabolic process • aspartate catabolic process • D-amino acid catabolic process • oxidation-reduction process • glyoxylate metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8528	70503
Ensembl	ENSG00000203797	ENSMUSG00000063428
UniProt	Q99489	Q922Z0
RefSeq (mRNA)	NM_003649 NM_004032	NM_027442 NM_001316716 NM_001316717 NM_001316718 NM_001316719
RefSeq (protein)	NP_003640.2 NP_004023.2	NP_001303645.1 NP_001303646.1 NP_001303647.1 NP_001303648.1 NP_081718.2
Location (UCSC)	Chr 6: 110.39 – 110.42 Mb	Chr 10: 40.63 – 40.65 Mb
PubMed search	[1]	[2]
Wikidata

D-aspartate oxidase is an enzyme that is encoded by the DDO gene.^[3][4]

The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two (or four, according to Q99489) transcript variants encoding different isoforms have been found for this gene.^[4]

References

Further reading