Cysteamine dioxygenase

In enzymology, a cysteamine dioxygenase (EC 1.13.11.19) is an enzyme that catalyzes the chemical reaction

2-aminoethanethiol + O₂ hypotaurine

Thus, the two substrates of this enzyme are 2-aminoethanethiol and O₂, whereas its product is hypotaurine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 2-aminoethanethiol:oxygen oxidoreductase. Other names in common use include persulfurase, cysteamine oxygenase, and cysteamine:oxygen oxidoreductase. This enzyme participates in taurine and hypotaurine metabolism. It employs one cofactor, iron.

References

• Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT (1966). "The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme". J. Biol. Chem. 241 (13): 3189–96. PMID 5912113. 
• Wood JL, Cavallini D (1967). "Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor". Arch. Biochem. Biophys. 119 (1): 368–72. doi:10.1016/0003-9861(67)90467-5. PMID 6052430. 
• Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A (1975). "The specificity of cysteamine oxygenase". FEBS Lett. 56 (2): 348–51. doi:10.1016/0014-5793(75)81124-0. PMID 1157952. 
• Richerson RB, Ziegler DM (1987). "Sulfur and Sulfur Amino Acids. Cysteamine dioxygenase". Methods Enzymol. Methods in Enzymology. 143: 410–5. doi:10.1016/0076-6879(87)43071-1. ISBN 978-0-12-182043-5. PMID 3657558.