Cycloartenol synthase
cycloartenol synthase | |||||||||
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Identifiers | |||||||||
EC number | 5.4.99.8 | ||||||||
CAS number | 9075-25-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a cycloartenol synthase (EC 5.4.99.8) is an enzyme that catalyzes the chemical reaction
- (S)-2,3-epoxysqualene cycloartenol
Hence, this enzyme has one substrate, (S)-2,3-epoxysqualene, and one product, cycloartenol.
This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming). Other names in common use include 2,3-epoxysqualene cycloartenol-cyclase, squalene-2,3-epoxide-cycloartenol cyclase, 2,3-epoxysqualene cycloartenol-cyclase, 2,3-epoxysqualene-cycloartenol cyclase, and 2,3-oxidosqualene-cycloartenol cyclase. This enzyme participates in biosynthesis of steroids.
References
- Rees HH, Goad LJ, Goodwin TW (1969). "2,3-oxidosqualene cycloartenol cyclase from Ochromonas malhamensis". Biochim. Biophys. Acta. 176 (4): 892–4. doi:10.1016/0005-2760(69)90274-4. PMID 5797101.
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