Costunolide synthase
| Costunolide synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.120 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Costunolide synthase (EC 1.14.13.120) is an enzyme with systematic name germacra-1(10),4,11(13)-trien-12-oate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating).[1] This enzyme catalyses the following chemical reaction
- germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2 (+)-costunolide + NADP+ + 2 H2O
Costunolide synthase is a heme-thiolate protein (P-450).
References
- ↑ de Kraker, J.W.; Franssen, M.C.; Joerink, M.; de Groot, A.; Bouwmeester, H.J. (2002). "Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome p450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory". Plant Physiol. 129 (1): 257–268. doi:10.1104/pp.010957. PMC 155889
. PMID 12011356.
External links
- Costunolide synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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