Cockscomb cervix
Cockscomb cervix is the condition wherein, as the name suggests, the cervix of the uterus is shaped like a cockscomb. About one third of women born to diethylstilbestrol-treated mothers (i.e. in-utero exposure) develop a cockscomb cervix.[1]
Enlarged folds or ridges of cervical stroma (fibrous tissues) and epithelium constitute a cockscomb cervix.[2] Similarly, cockscomb polyps lining the cervix are usually considered or grouped into the same overarching description. It is in and of itself considered a benign abnormality; its presence, however is usually indicative of DES exposure, and as such women who experience these abnormalities should be aware of their increased risk of associated pathologies.[3][4][5]
See also
References
- ↑ Casey, Petra M.; Long, Margaret E.; Marnach, Mary L. (2011). "Abnormal Cervical Appearance: What to Do, When to Worry?". Mayo Clinic Proceedings. 86 (2): 147–151. doi:10.4065/mcp.2010.0512. ISSN 0025-6196. PMC 3031439
. PMID 21270291. - ↑ "Diethylstilbestrol (DES) Cervix". National Cancer Institute Visuals. National Cancer Institute. Retrieved 14 May 2015.
- ↑ Wingfield, M (1991). "The daughters of stilboestrol.". BMJ. 302 (6790): 1414–1415. doi:10.1136/bmj.302.6790.1414. ISSN 0959-8138.
- ↑ Mittendorf, Robert (1995). "Teratogen update: Carcinogenesis and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero". Teratology. 51 (6): 435–445. doi:10.1002/tera.1420510609. ISSN 0040-3709.
- ↑ Herbst, Arthur L.; Poskanzer, David C.; Robboy, Stanley J.; Friedlander, Lawrence; Scully, Robert E. (1975). "Prenatal Exposure to Stilbestrol". New England Journal of Medicine. 292 (7): 334–339. doi:10.1056/NEJM197502132920704. ISSN 0028-4793.
Further reading
- O'BRIEN, PETER C., et al. "Vaginal epithelial changes in young women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) project." Obstetrics & Gynecology 53.3 (1979): 300-308.
- D. P. Goldstein (July 1978). "Incompetent cervix in offspring exposed to diethylstilbestrol in utero". Obstetrics and gynecology. 52 (1 Suppl): 73S–75S. PMID 683647.
- Auclair, Carolyn Abernethy (1979). "Consequences of Prenatal Exposure to Diethylstilbestrol". Journal of Obstetric, Gynecologic, & Neonatal Nursing. 8 (1): 35–39. doi:10.1111/j.1552-6909.1979.tb00795.x. ISSN 0884-2175.
- Candice A. Tedeschi, Mary Rubin & Burton A. Krumholz (January 2005). "Six cases of women with diethylstilbestrol in utero demonstrating long-term manifestations and current evaluation guidelines". Journal of lower genital tract disease. 9 (1): 11–18. doi:10.1097/00128360-200501000-00004. PMID 15870516.
- A. L. Herbst (November 1981). "Diethylstilbestrol and other sex hormones during pregnancy". Obstetrics and gynecology. 58 (5 Suppl): 35S–40S. PMID 7031540.
- K. L. Noller, D. G. Decker, C. R. Fish & T. A. Gaffey (September 1976). "Identification, examination, and management of diethylstilbestrol-exposed offspring". Clinical obstetrics and gynecology. 19 (3): 699–705. doi:10.1097/00003081-197609000-00017. PMID 954256.
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