Chorionic gonadotropin beta

CGB3

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1HCN, 1HRP, 1QFW

Identifiers

Aliases

CGB3, CGB5, CGB7, CGB8, hCGB, CGB, Chorionic gonadotropin beta, chorionic gonadotropin beta subunit 3, Choriogonadotropin subunit beta

External IDs

HomoloGene: 37338 GeneCards: CGB3

Gene ontology
Molecular function	• hormone activity
Cellular component	• extracellular region
Biological process	• peptide hormone processing • apoptotic process • cellular protein metabolic process • signal transduction • female gamete generation • cell-cell signaling
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1082


n/a

Ensembl


ENSG00000104827


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UniProt


P01233


n/a

RefSeq (mRNA)


NM_000737


n/a

RefSeq (protein)


NP_000728.1 NP_149032.1 NP_149133.1 NP_149439.1


n/a

Location (UCSC)

Chr 19: 49.02 – 49.02 Mb

n/a

PubMed search

^[1]

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Wikidata

View/Edit Human

Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is encoded by the CGB gene.^[2]^[3]^[4]

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.^[2]

References

↑ "Human PubMed Reference:".
1 2 "Entrez Gene: chorionic gonadotropin".
↑ Fiddes JC, Goodman HM (August 1980). "The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region". Nature. 286 (5774): 684–7. doi:10.1038/286684a0. PMID 6774259.
↑ Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (October 1983). "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J. Biol. Chem. 258 (19): 11492–9. PMID 6194155.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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