Chitin disaccharide deacetylase

Chitin disaccharide deacetylase (EC 3.5.1.105, chitobiose amidohydolase, COD, chitin oligosaccharide deacetylase, chitin oligosaccharide amidohydolase) is an enzyme with systematic name 2-(acetylamino)-4-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucopyranose acetylhydrolase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H₂O

\rightleftharpoons

2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate

Chitin oligosaccharide deacetylase is present in Vibrio strains.

References

↑ Kadokura, K.; Rokutani, A.; Yamamoto, M.; Ikegami, T.; Sugita, H.; Itoi, S.; Hakamata, W.; Oku, T.; Nishio, T. (2007). "Purification and characterization of Vibrio parahaemolyticus extracellular chitinase and chitin oligosaccharide deacetylase involved in the production of heterodisaccharide from chitin". Appl. Microbiol. Biotechnol. 75: 357–365. doi:10.1007/s00253-006-0831-6. PMID 17334758.
↑ Hirano, T.; Kadokura, K.; Ikegami, T.; Shigeta, Y.; Kumaki, Y.; Hakamata, W.; Oku, T.; Nishio, T. (2009). "Heterodisaccharide 4-O-(N-acetyl-β-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes". Glycobiology. 19: 1046–1053. doi:10.1093/glycob/cwp088. PMID 19553519.
↑ Ohishi, K.; Yamagishi, M.; Ohta, T.; Motosugi, M.; Izumida, H.; Sano, H.; Adachi, K.; Miwa, T. (1997). "Purification and properties of two deacetylases produced by Vibrio alginolyticus H-8". Biosci. Biotechnol. Biochem. 61: 1113–1117. doi:10.1271/bbb.61.1113.
↑ Ohishi, K.; Murase, K.; Ohta, T.; Etoh, H. (2000). "Cloning and sequencing of the deacetylase gene from Vibrio alginolyticus H-8". J. Biosci. Bioeng. 90: 561–563. doi:10.1263/jbb.90.561. PMID 16232910.

External links

Chitin disaccharide deacetylase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolases: carbon-nitrogen non-peptide (EC 3.5)

3.5.1: Linear amides / Amidohydrolases	Asparaginase Glutaminase Urease Biotinidase Aspartoacylase Ceramidase Aspartylglucosaminidase Fatty acid amide hydrolase Histone deacetylase Sirtuin

3.5.2: Cyclic amides/ Amidohydrolases	Barbiturase Beta-lactamase

3.5.3: Linear amidines/ Ureohydrolases	Arginase Agmatinase Protein-arginine deiminase

3.5.4: Cyclic amidines/ Aminohydrolases	Guanine deaminase Adenosine deaminase AMP deaminase Inosine monophosphate synthase DCMP deaminase GTP cyclohydrolase I Cytidine deaminase AICDA Activation-induced cytidine deaminase

3.5.5: Nitriles/ Aminohydrolases	Nitrilase

3.5.99: Other	Riboflavinase Thiaminase II

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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