Chemical formula

Structural formula for n-butane. This is not a chemical formula. Examples of chemical formulas for n-butane are the empirical formula C2H5, the molecular formula C4H10 and the condensed (or semi-structural) formula CH3CH2CH2CH3.

A chemical formula is a way of expressing information about the proportions of atoms that constitute a particular chemical compound, using a single line of chemical element symbols, numbers, and sometimes also other symbols, such as parentheses, dashes, brackets, commas and plus (+) and minus (−) signs. These are limited to a single typographic line of symbols, which may include subscripts and superscripts. A chemical formula is not a chemical name, and it contains no words. Although a chemical formula may imply certain simple chemical structures, it is not the same as a full chemical structural formula. Chemical formulas can fully specify the structure of only the simplest of molecules and chemical substances, and are generally more limited in power than are chemical names and structural formulas.

The simplest types of chemical formulas are called empirical formulas, which use letters and numbers indicating the numerical proportions of atoms of each type. Molecular formulas indicate the simple numbers of each type of atom in a molecule, with no information on structure. For example, the empirical formula for glucose is CH₂O (twice as many hydrogen atoms as carbon and oxygen), while its molecular formula is C₆H₁₂O₆ (12 hydrogen atoms, six carbon and oxygen atoms).

Sometimes a chemical formula is complicated by being written as a condensed formula (or condensed molecular formula, occasionally called a "semi-structural formula"), which conveys additional information about the particular ways in which the atoms are chemically bonded together, either in covalent bonds, ionic bonds, or various combinations of these types. This is possible if the relevant bonding is easy to show in one dimension. An example is the condensed molecular/chemical formula for ethanol, which is CH₃-CH₂-OH or CH₃CH₂OH. However, even a condensed chemical formula is necessarily limited in its ability to show complex bonding relationships between atoms, especially atoms that have bonds to four or more different substituents.

Since a chemical formula must be expressed as a single line of chemical element symbols, it often cannot be as informative as a true structural formula, which is a graphical representation of the spatial relationship between atoms in chemical compounds (see for example the figure for butane structural and chemical formulas, at right). For reasons of structural complexity, there is no condensed chemical formula (or semi-structural formula) that specifies glucose (and there exist many different molecules, for example fructose and mannose, have the same molecular formula C₆H₁₂O₆ as glucose). Linear equivalent chemical names exist that can and do specify any complex structural formula (see chemical nomenclature), but such names must use many terms (words), rather than the simple element symbols, numbers, and simple typographical symbols that define a chemical formula.

Chemical formulas may be used in chemical equations to describe chemical reactions and other chemical transformations, such as the dissolving of ionic compounds into solution. While, as noted, chemical formulas do not have the full power of structural formulas to show chemical relationships between atoms, they are sufficient to keep track of numbers of atoms and numbers of electrical charges in chemical reactions, thus balancing chemical equations so that these equations can be used in chemical problems involving conservation of atoms, and conservation of electric charge.

Overview

A chemical formula identifies each constituent element by its chemical symbol and indicates the proportionate number of atoms of each element. In empirical formulas, these proportions begin with a key element and then assign numbers of atoms of the other elements in the compound, as ratios to the key element. For molecular compounds, these ratio numbers can all be expressed as whole numbers. For example, the empirical formula of ethanol may be written C₂H₆O because the molecules of ethanol all contain two carbon atoms, six hydrogen atoms, and one oxygen atom. Some types of ionic compounds, however, cannot be written with entirely whole-number empirical formulas. An example is boron carbide, whose formula of CB_n is a variable non-whole number ratio with n ranging from over 4 to more than 6.5.

When the chemical compound of the formula consists of simple molecules, chemical formulas often employ ways to suggest the structure of the molecule. These types of formulas are variously known as molecular formulas and condensed formulas. A molecular formula enumerates the number of atoms to reflect those in the molecule, so that the molecular formula for glucose is C₆H₁₂O₆ rather than the glucose empirical formula, which is CH₂O. However, except for very simple substances, molecular chemical formulas lack needed structural information, and are ambiguous.

For simple molecules, a condensed (or semi-structural) formula is a type of chemical formula that may fully imply a correct structural formula. For example, ethanol may be represented by the condensed chemical formula CH₃CH₂OH, and dimethyl ether by the condensed formula CH₃OCH₃. These two molecules have the same empirical and molecular formulas (C₂H₆O), but may be differentiated by the condensed formulas shown, which are sufficient to represent the full structure of these simple organic compounds.

Condensed chemical formulas may also be used to represent ionic compounds that do not exist as discrete molecules, but nonetheless do contain covalently bound clusters within them. These polyatomic ions are groups of atoms that are covalently bound together and have an overall ionic charge, such as the sulfate [SO
4]2−
ion. Each polyatomic ion in a compound is written individually in order to illustrate the separate groupings. For example, the compound dichlorine hexoxide has an empirical formula ClO
3, and molecular formula Cl
2O
6, but in liquid or solid forms, this compound is more correctly shown by an ionic condensed formula [ClO
2]+
[ClO
4]−
, which illustrates that this compound consists of [ClO
2]+
ions and [ClO
4]−
ions. In such cases, the condensed formula only need be complex enough to show at least one of each ionic species.

Chemical formulas as described here are distinct from the far more complex chemical systematic names that are used in various systems of chemical nomenclature. For example, one systematic name for glucose is (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal. This name, interpreted by the rules behind it, fully specifies glucose's structural formula, but the name is not a chemical formula as usually understood, and uses terms and words not used in chemical formulas. Such names, unlike basic formulas, may be able to represent full structural formulas without graphs.

Empirical formula

In chemistry, the empirical formula of a chemical is a simple expression of the relative number of each type of atom or ratio of the elements in the compound. Empirical formulas are the standard for ionic compounds, such as CaCl
2, and for macromolecules, such as SiO
2. An empirical formula makes no reference to isomerism, structure, or absolute number of atoms. The term empirical refers to the process of elemental analysis, a technique of analytical chemistry used to determine the relative percent composition of a pure chemical substance by element.

For example, hexane has a molecular formula of C
6H
14, or structurally CH
3CH
2CH
2CH
2CH
2CH
3, implying that it has a chain structure of 6 carbon atoms, and 14 hydrogen atoms. However, the empirical formula for hexane is C
3H
7. Likewise the empirical formula for hydrogen peroxide, H
2O
2, is simply HO expressing the 1:1 ratio of component elements. Formaldehyde and acetic acid have the same empirical formula, CH
2O. This is the actual chemical formula for formaldehyde, but acetic acid has double the number of atoms.

Molecular formula

Molecular formulas indicate the simple numbers of each type of atom in a molecule of a molecular substance. They are the same as empirical formulas for molecules that only have one atom of a particular type, but otherwise have larger numbers. An example of the difference is the empirical formula for glucose, which is CH₂O (ratio 1:2:1), while its molecular formula is C₆H₁₂O₆ (number of atoms 6:12:6). For water, both formulas are H₂O. A molecular formula provides more information about a molecule than its empirical formula, but is more difficult to establish.

A molecular formulae shows the number of elements in a molecule, and determines whether it is a binary compound, ternary compound, quaternary compound or has even more elements.

Condensed formula

In organic chemistry implying molecular geometry and structural formulas

Isobutane structural formula
Molecular formula: C₄H₁₀
Condensed or semi-structural chemical formula: (CH₃)₃CH

n-Butane structural formula
Molecular formula: C₄H₁₀
Condensed or semi-structural formula: CH₃CH₂CH₂CH₃

The connectivity of a molecule often has a strong influence on its physical and chemical properties and behavior. Two molecules composed of the same numbers of the same types of atoms (i.e. a pair of isomers) might have completely different chemical and/or physical properties if the atoms are connected differently or in different positions. In such cases, a structural formula is useful, as it illustrates which atoms are bonded to which other ones. From the connectivity, it is often possible to deduce the approximate shape of the molecule.

A condensed chemical formula may represent the types and spatial arrangement of bonds in a simple chemical substance, though it does not necessarily specify isomers or complex structures. For example, ethane consists of two carbon atoms single-bonded to each other, with each carbon atom having three hydrogen atoms bonded to it. Its chemical formula can be rendered as CH₃CH₃. In ethylene there is a double bond between the carbon atoms (and thus each carbon only has two hydrogens), therefore the chemical formula may be written: CH₂CH₂, and the fact that there is a double bond between the carbons is implicit because carbon has a valence of four. However, a more explicit method is to write H₂C=CH₂ or less commonly H₂C::CH₂. The two lines (or two pairs of dots) indicate that a double bond connects the atoms on either side of them.

A triple bond may be expressed with three lines or pairs of dots, and if there may be ambiguity, a single line or pair of dots may be used to indicate a single bond.

Molecules with multiple functional groups that are the same may be expressed by enclosing the repeated group in round brackets. For example, isobutane may be written (CH₃)₃CH. This condensed structural formula implies a different connectivity from other molecules that can be formed using the same atoms in the same proportions (isomers). The formula (CH₃)₃CH implies a central carbon atom connected to one hydrogen atom and three CH₃ groups. The same number of atoms of each element (10 hydrogens and 4 carbons, or C₄H₁₀) may be used to make a straight chain molecule, n-butane: CH₃CH₂CH₂CH₃.

Law of composition

In any given chemical compound, the elements always combine in the same proportion with each other. This is the law of constant composition.

The law of constant composition says that, in any particular chemical compound, all samples of that compound will be made up of the same elements in the same proportion or ratio. For example, any water molecule is always made up of two hydrogen atoms and one oxygen atom in a 2:1 ratio. If we look at the relative masses of oxygen and hydrogen in a water molecule, we see that 94% of the mass of a water molecule is accounted for by oxygen and the remaining 6% is the mass of hydrogen. This mass proportion will be the same for any water molecule.^[1]

Chemical names in answer to limitations of chemical formulas

The alkene called but-2-ene has two isomers, which the chemical formula CH₃CH=CHCH₃ does not identify. The relative position of the two methyl groups must be indicated by additional notation denoting whether the methyl groups are on the same side of the double bond (cis or Z) or on the opposite sides from each other (trans or E). Such extra symbols violate the rules for chemical formulas, and begin to enter the territory of more complex naming systems.

As noted above, in order to represent the full structural formulas of many complex organic and inorganic compounds, chemical nomenclature may be needed which goes well beyond the available resources used above in simple condensed formulas. See IUPAC nomenclature of organic chemistry and IUPAC nomenclature of inorganic chemistry 2005 for examples. In addition, linear naming systems such as International Chemical Identifier (InChI) allow a computer to construct a structural formula, and simplified molecular-input line-entry system (SMILES) allows a more human-readable ASCII input. However, all these nomenclature systems go beyond the standards of chemical formulas, and technically are chemical naming systems, not formula systems.

Polymers in condensed formulas

For polymers in condensed chemical formulas, parentheses are placed around the repeating unit. For example, a hydrocarbon molecule that is described as CH₃(CH₂)₅₀CH₃, is a molecule with fifty repeating units. If the number of repeating units is unknown or variable, the letter n may be used to indicate this formula: CH₃(CH₂)_nCH₃.

Ions in condensed formulas

For ions, the charge on a particular atom may be denoted with a right-hand superscript. For example, Na⁺, or Cu²⁺. The total charge on a charged molecule or a polyatomic ion may also be shown in this way. For example: H₃O⁺ or SO₄²⁻.

For more complex ions, brackets [ ] are often used to enclose the ionic formula, as in [B₁₂H₁₂]²⁻, which is found in compounds such as Cs₂[B₁₂H₁₂]. Parentheses ( ) can be nested inside brackets to indicate a repeating unit, as in [Co(NH₃)₆]³⁺. Here (NH₃)₆ indicates that the ion contains six [ammine|NH₃ groups], and [ ] encloses the entire formula of the ion with charge +3.

Isotopes

Although isotopes are more relevant to nuclear chemistry or stable isotope chemistry than to conventional chemistry, different isotopes may be indicated with a prefixed superscript in a chemical formula. For example, the phosphate ion containing radioactive phosphorus-32 is ³²PO₄³⁻. Also a study involving stable isotope ratios might include the molecule ¹⁸O¹⁶O.

A left-hand subscript is sometimes used redundantly to indicate the atomic number. For example, ₈O₂ for dioxygen, and ¹⁶₈O₂ for the most abundant isotopic species of dioxygen. This is convenient when writing equations for nuclear reactions, in order to show the balance of charge more clearly.

Trapped atoms

Traditional formula: MC₆₀
The "@" notation: M@C₆₀

The @ symbol (at sign) indicates an atom or molecule trapped inside a cage but not chemically bound to it. For example, a buckminsterfullerene (C₆₀) with an atom (M) would simply be represented as MC₆₀ regardless of whether M was inside the fullerene without chemical bonding or outside, bound to one of the carbon atoms. Using the @ symbol, this would be denoted M@C₆₀ if M was inside the carbon network. A non-fullerene example is [As@Ni₁₂As₂₀]³⁻, an ion in which one As atom is trapped in a cage formed by the other 32 atoms.

This notation was proposed in 1991^[2] with the discovery of fullerene cages (endohedral fullerenes), which can trap atoms such as La to form, for example, La@C₆₀ or La@C₈₂. The choice of the symbol has been explained by the authors as being concise, readily printed and transmitted electronically (the at sign is included in ASCII, which most modern character encoding schemes are based on), and the visual aspects suggesting the structure of an endohedral fullerene.

Non-stoichiometric chemical formulas

Chemical formulas most often use integers for each element. However, there is a class of compounds, called non-stoichiometric compounds, that cannot be represented by small integers. Such a formula might be written using decimal fractions, as in Fe_0.95O, or it might include a variable part represented by a letter, as in Fe_1–xO, where x is normally much less than 1.

General forms for organic compounds

A chemical formula used for a series of compounds that differ from each other by a constant unit is called general formula. Such a series is called the homologous series, while its members are called homologs.
For example, alcohols may be represented by: C_nH_{(2n + 1)}OH (n ≥ 1)

Hill system

The Hill system (or Hill notation) is a system of writing empirical chemical formulas, molecular chemical formulas and components of a condensed formula such that the number of carbon atoms in a molecule is indicated first, the number of hydrogen atoms next, and then the number of all other chemical elements subsequently, in alphabetical order of the chemical symbols. When the formula contains no carbon, all the elements, including hydrogen, are listed alphabetically.

By sorting formulas according to the number of atoms of each element present in the formula according to these rules, with differences in earlier elements or numbers being treated as more significant than differences in any later element or number—like sorting text strings into lexicographical order—it is possible to collate chemical formulas into what is known as Hill system order.

The Hill system was first published by Edwin A. Hill of the United States Patent and Trademark Office in 1900.^[3] It is the most commonly used system in chemical databases and printed indexes to sort lists of compounds.^[4]

Examples: The following formulas are written using the Hill system, and listed in Hill order:

• BrI
• CCl₄
• CH₃I
• C₂H₅Br
• H₂O₄S

A list of formulas in Hill system order is arranged alphabetically, as above, with single-letter elements coming before two-letter symbols when the symbols begin with the same letter (so "B" comes before "Be", which comes before "Br").^[4]

See also

• Dictionary of chemical formulas
• Element symbol
• Nuclear notation
• Periodic table
• IUPAC nomenclature of inorganic chemistry
• Formula unit

References

Wikidata has the property: chemical formula (P274) (see uses)

• Ralph S. Petrucci; William S. Harwood; F. Geoffrey Herring (2002). "3". General Chemistry: Principles and Modern Applications (8th ed.). Prentice-Hall. ISBN 0-13-198825-5. OCLC 46872308. 

External links

• Hill notation example, from the University of Massachusetts Lowell libraries, including how to sort into Hill system order
• Molecular formula calculation applying Hill notation. The library calculating Hill notation is available on npm.

Molecules detected in outer space
Molecules	Diatomic Aluminium monochloride Aluminium monofluoride Aluminium monoxide Argonium Carbon monophosphide Carbon monosulfide Carbon monoxide Carborundum Cyanogen radical Diatomic carbon Fluoromethylidynium Hydrogen chloride Hydrogen fluoride Hydrogen (molecular) Hydroxyl radical Iron(II) oxide Magnesium monohydride cation Methylidyne radical Nitric oxide Nitrogen (molecular) Nitrogen monohydride Nitrogen sulfide Oxygen (molecular) Phosphorus monoxide Phosphorus mononitride Potassium chloride Silicon carbide Silicon mononitride Silicon monoxide Silicon monosulfide Sodium chloride Sodium iodide Sulfur monohydride Sulfur monoxide Titanium oxide Triatomic Aluminium hydroxide Aluminium isocyanide Amino radical Carbon dioxide Carbonyl sulfide CCP radical Chloronium Diazenylium Dicarbon monoxide Disilicon carbide Ethynyl radical Formyl radical Hydrogen cyanide (HCN) Hydrogen isocyanide (HNC) Hydrogen sulfide Hydroperoxyl Iron cyanide Isoformyl Magnesium cyanide Magnesium isocyanide Methylene radical N2H+ Nitrous oxide Nitroxyl Ozone Phosphaethyne Potassium cyanide Protonated molecular hydrogen Sodium cyanide Sodium hydroxide Silicon carbonitride c-Silicon dicarbide Silicon naphthalocyanine Sulfur dioxide Thioformyl Thioxoethenylidene Titanium dioxide Tricarbon Water Four atoms Acetylene Ammonia Cyanic acid Cyanoethynyl Cyclopropynylidyne Formaldehyde Fulminic acid HCCN Hydrogen peroxide Hydromagnesium isocyanide Isocyanic acid Isothiocyanic acid Ketenyl Methylene amidogen Methyl radical Propynylidyne Protonated carbon dioxide Protonated hydrogen cyanide Silicon tricarbide Thioformaldehyde Tricarbon monoxide Tricarbon sulfide Thiocyanic acid Five atoms Ammonium ion Butadiynyl Carbodiimide Cyanamide Cyanoacetylene Cyanoformaldehyde Cyanomethyl Cyclopropenylidene Formic acid Isocyanoacetylene Ketene Methane Methoxy radical Methylenimine Propadienylidene Protonated formaldehyde Protonated formaldehyde Silane Silicon-carbide cluster Six atoms Acetonitrile Cyanobutadiynyl radical E-Cyanomethanimine Cyclopropenone Diacetylene Ethylene Formamide HC4N Ketenimine Methanethiol Methanol Methyl isocyanide Pentynylidyne Propynal Protonated cyanoacetylene Seven atoms Acetaldehyde Acrylonitrile Cyanodiacetylene Ethylene oxide Hexatriynyl radical Methylacetylene Methylamine Methyl isocyanate Vinyl alcohol Eight atoms Acetic acid Aminoacetonitrile Cyanoallene Ethanimine Glycolaldehyde Heptatrienyl radical Hexapentaenylidene Methylcyanoacetylene Methyl formate Propenal Nine atoms Acetamide Cyanohexatriyne Cyanotriacetylene Dimethyl ether Ethanol Methyldiacetylene Octatetraynyl radical Propene Propionitrile Ten atoms or more Acetone Benzene Buckminsterfullerene (C60 fullerene, buckyball) C70 fullerene Cyanodecapentayne Cyanopentaacetylene Cyanotetra-acetylene Ethylene glycol Ethyl formate Methyl acetate Methyl-cyano-diacetylene Methyltriacetylene Propanal n-Propyl cyanide Pyrimidine
Deuterated molecules	Ammonia Ammonium ion Formaldehyde Formyl radical Heavy water Hydrogen cyanide Hydrogen deuteride Hydrogen isocyanide Methylacetylene N2D+ Trihydrogen cation
Unconfirmed	Anthracene Dihydroxyacetone Ethyl methyl ether Glycine Graphene H2NCO+ Linear C5 Naphthalene cation Phosphine Pyrene Silylidine
Related	Abiogenesis Astrobiology Astrochemistry Atomic and molecular astrophysics Chemical formula Circumstellar envelope Cosmic dust Cosmic ray Cosmochemistry Diffuse interstellar band Extraterrestrial life Extraterrestrial liquid water Forbidden mechanism Helium hydride ion Homochirality Intergalactic dust Interplanetary medium Interstellar medium Iron–sulfur world theory Kerogen Life Life timeline Molecules in stars Nature timeline Nexus for Exoplanet System Science Organic compound Outer space PAH world hypothesis Panspermia Polycyclic aromatic hydrocarbon (PAH) RNA world hypothesis Spectroscopy Tholin
Book:Chemistry Category:Astrochemistry Category:Molecules Portal:Astrobiology Portal:Astronomy Portal:Chemistry