Cephaeline

Not to be confused with cephalin.
Cephaeline
Names
IUPAC name
(1R)-1-[[(2S,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol
Other names
Cepheline; Desmethylemetine; Dihydropsychotrine
Identifiers
483-17-0 YesY
3D model (Jmol) Interactive image
ChEMBL ChEMBL255708 YesY
ChemSpider 390702 YesY
ECHA InfoCard 100.006.902
PubChem 442195
UNII QA971541A1 YesY
Properties
C28H38N2O4
Molar mass 466.62 g·mol−1
Appearance White silky crystals
Solubility in ethanol Soluble
Hazards
Main hazards Emetic / poisonous
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Cephaeline is an alkaloid that is found in Cephaelis ipecacuanha and other plant species including Psychotria acuminata.[1] Cephaeline induces vomiting by stimulating the stomach lining and is found in commercial products such as syrup of ipecac.[2] Chemically, it is closely related to emetine.

Poison treatment

Cephaeline in the form of syrup of ipecac was once commonly recommended as an emergency treatment for accidental poisoning, but its use has been phased out due to its ineffectiveness.[3]

References

  1. Lara, Alfonso; Valverde, Roberto; Gomez, Luis; Hidalgo, Nancy (July 1, 2003). "Micropropagacion de la planta medicinal psychotria acuminata". Agronomía Costarricense. Retrieved 26 December 2009.
  2. "Pharma Japan: Approval of 4 drugs including Seroquel recommended: CPAC panel.". Chemical Business Newsbase. November 14, 2000. Retrieved 26 December 2009.
  3. "Policy statement: Poison treatment in the home". Pediatrics. 112 (5): 1182–1185. November 2003. doi:10.1542/peds.112.5.1182. PMID 14595067. Retrieved 31 December 2009.
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