Cathepsin O

CTSO
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases CTSO, CTSO1, cathepsin O
External IDs OMIM: 600550 MGI: 2139628 HomoloGene: 1020 GeneCards: CTSO
Orthologs
Species Human Mouse
Entrez

1519

229445

Ensembl

n/a

ENSMUSG00000028015

UniProt

P43234

Q8BM88

RefSeq (mRNA)

NM_001334

NM_177662

RefSeq (protein)

NP_001325.1

NP_808330.1

Location (UCSC) Chr 4: 155.92 – 155.95 Mb Chr 3: 81.93 – 81.96 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Cathepsin O is an enzyme that in humans is encoded by the CTSO gene.[3][4]

Function

Cathepsin O is a cysteine protease and a member of the cathepsin family and papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Santamaría I, Pendás AM, Velasco G, López-Otín C (October 1998). "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)". Genomics. 53 (2): 231–4. doi:10.1006/geno.1997.5180. PMID 9790772.
  4. 1 2 "Entrez Gene: cathepsin O".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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