CDH17

CDH17
Identifiers
Aliases CDH17, CDH16, HPT-1, HPT1, cadherin 17
External IDs MGI: 1095414 HomoloGene: 56859 GeneCards: CDH17
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

1015

12557

Ensembl

ENSG00000079112

ENSMUSG00000028217

UniProt

Q12864

Q9R100

RefSeq (mRNA)

NM_001144663
NM_004063

NM_019753

RefSeq (protein)

NP_001138135.1
NP_004054.3

NP_062727.1

Location (UCSC) Chr 8: 94.13 – 94.22 Mb Chr 4: 11.76 – 11.82 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.[3][4][5]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
  4. Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
  5. 1 2 "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)".

Further reading

External links


This article is issued from Wikipedia - version of the 6/6/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.