CDC16

CDC16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HYM, 4UI9, 5A31, 5G04, 5G05
Identifiers
Aliases	CDC16, ANAPC6, APC6, CUT9, CDC16Hs, cell division cycle 16
External IDs	MGI: 1917207 HomoloGene: 2899 GeneCards: CDC16
Gene ontology Molecular function • protein binding Cellular component • microtubule organizing center • nucleus • spindle microtubule • anaphase-promoting complex • cytoskeleton • nucleoplasm • cytosol • cytoplasm • centrosome • spindle Biological process • protein K11-linked ubiquitination • regulation of mitotic nuclear division • anaphase-promoting complex-dependent catabolic process • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • cell proliferation • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • protein ubiquitination • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • cell division • cell cycle • mitotic nuclear division • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8881	69957
Ensembl	ENSG00000130177	ENSMUSG00000038416
UniProt	Q13042	Q8R349
RefSeq (mRNA)	NM_001078645 NM_003903 NM_001318517 NM_001318518	NM_027276
RefSeq (protein)	NP_001072113.1 NP_003894.3 NP_001305446.1 NP_001305447.1	NP_081552.2
Location (UCSC)	Chr 13: 114.23 – 114.27 Mb	Chr 8: 13.76 – 13.78 Mb
PubMed search	[1]	[2]
Wikidata

Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.^[3][4]

Function

This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.^[4]

Interactions

CDC16 has been shown to interact with CDC27^[5][6][7][8] and CDC20.^{[5][7][9][10]}

References

Further reading