Calmodulin 1

CALM1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2VAY, 1Y6W, 4JPZ, 3UCY, 1WRZ, 4G28, 1ZOT, 1YRT, 1IQ5, 1CDL, 2LL6, 3HR4, 4BW7, 4BW8, 1YR5, 4J9Y, 4LZX, 1L7Z, 1ZUZ, 2BE6, 2V01, 1XFV, 2M55, 1CTR, 2I08, 2MG5, 2R28, 3O77, 4UPU, 2L7L, 2K0F, 2M0K, 4V0C, 1SW8, 2WEL, 3DVK, 2M0J, 3DVM, 2KUH, 1K90, 1K93, 4G27, 1CLL, 2KUG, 1XFX, 4DJC, 2LQC, 2LQP, 4L79, 2W73, 2LV6, 1NKF, 2JZI, 3UCT, 4GOW, 1J7O, 1PK0, 4Q5U, 2V02, 3BYA, 4Q57, 2KNE, 1YRU, 2Y4V, 2L53, 2F3Y, 3O78, 1LVC, 4M1L, 2K0E, 1S26, 4DCK, 1XFW, 3SUI, 2X0G, 3EWV, 1XFY, 2LL7, 4OVN, 3J41, 2BKI, 1SK6, 3DVJ, 3UCW, 2LGF, 4UMO, 3DVE, 4JQ0, 3OXQ, 2K61, 1XFU, 3SJQ, 2K0J, 4BYF, 1J7P, 3G43, 3EWT, 4J9Z, 1XFZ, 2F3Z, 1IWQ, 2N6A, 2HF5, 2N27, 4ZLK, 5COC
Identifiers
Aliases	CALM1, CALML2, CAMI, CPVT4, DD132, PHKD, caM, LQT14, Calmodulin 1, calmodulin 1 (phosphorylase kinase, delta)
External IDs	HomoloGene: 134804 GeneCards: CALM1
Gene ontology Molecular function • calcium ion binding • protein phosphatase activator activity • N-terminal myristoylation domain binding • phospholipase binding • ion channel binding • protein domain specific binding • protein N-terminus binding • calcium-dependent protein binding • nitric-oxide synthase regulator activity • nitric-oxide synthase binding • adenylate cyclase binding • enzyme regulator activity • titin binding • metal ion binding • type 3 metabotropic glutamate receptor binding • protein serine/threonine kinase activator activity • protein binding • thioesterase binding • protein kinase binding • phosphatidylinositol 3-kinase binding • ligand-gated ion channel activity • Ras guanyl-nucleotide exchange factor activity • inositol-1,4,5-trisphosphate 3-kinase activity Cellular component • cytoplasm • cytosol • calcium channel complex • extracellular region • spindle microtubule • neuron projection • cytoskeleton • nucleus • centrosome • voltage-gated potassium channel complex • extracellular exosome • spindle pole • growth cone • plasma membrane • spindle • sarcomere • nucleoplasm • vesicle Biological process • muscle contraction • response to amphetamine • positive regulation of protein serine/threonine kinase activity • detection of calcium ion • Fc-epsilon receptor signaling pathway • positive regulation of cyclic nucleotide metabolic process • positive regulation of phosphoprotein phosphatase activity • G2/M transition of mitotic cell cycle • regulation of high voltage-gated calcium channel activity • positive regulation of DNA binding • substantia nigra development • positive regulation of protein dephosphorylation • inositol phosphate metabolic process • positive regulation of nitric-oxide synthase activity • glycogen catabolic process • positive regulation of cyclic-nucleotide phosphodiesterase activity • G-protein coupled receptor signaling pathway • regulation of cytokinesis • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • regulation of rhodopsin mediated signaling pathway • response to corticosterone • negative regulation of peptidyl-threonine phosphorylation • activation of adenylate cyclase activity • regulation of heart rate • positive regulation of ryanodine-sensitive calcium-release channel activity • response to calcium ion • regulation of ryanodine-sensitive calcium-release channel activity • regulation of nitric-oxide synthase activity • platelet degranulation • negative regulation of ryanodine-sensitive calcium-release channel activity • MAPK cascade • positive regulation of peptidyl-threonine phosphorylation • positive regulation of protein autophosphorylation • regulation of cardiac muscle contraction • regulation of cell communication by electrical coupling involved in cardiac conduction • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • calcium-mediated signaling • ion transmembrane transport • Wnt signaling pathway, calcium modulating pathway • positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	801	n/a
Ensembl	ENSG00000198668	n/a
UniProt	P62158	n/a
RefSeq (mRNA)	NM_001166106 NM_006888	n/a
RefSeq (protein)	NP_001292553.1 NP_001292554.1 NP_001292555.1 NP_001734.1 NP_005175.2 NP_008819.1	n/a
Location (UCSC)	Chr 14: 90.4 – 90.41 Mb	n/a
PubMed search	[1]	n/a
Wikidata

Calmodulin 1 is a protein that in humans is encoded by the CALM1 gene.^[2]

Function

Calmodulin 1 is the archetype of the family of calcium-modulated (calmodulin) proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 148 amino acids and has 4 calcium-binding EF hand motifs. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.^[3]

Interactions

Calmodulin 1 has been shown to interact with:

• AKAP9,^[4]
• Androgen receptor,^[5]
• IQGAP1,^[6][7]
• PPEF1,^[8] and
• TRPV1.^[9]

References

Further reading

PDB gallery
1a29: CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX)  1ahr: CALMODULIN MUTANT WITH A TWO RESIDUE DELETION IN THE CENTRAL HELIX  1ak8: NMR SOLUTION STRUCTURE OF CERIUM-LOADED CALMODULIN AMINO-TERMINAL DOMAIN (CE2-TR1C), 23 STRUCTURES  1cdl: TARGET ENZYME RECOGNITION BY CALMODULIN: 2.4 ANGSTROMS STRUCTURE OF A CALMODULIN-PEPTIDE COMPLEX  1cdm: MODULATION OF CALMODULIN PLASTICITY IN MOLECULAR RECOGNITION ON THE BASIS OF X-RAY STRUCTURES  1cfc: CALCIUM-FREE CALMODULIN  1cfd: CALCIUM-FREE CALMODULIN  1cff: NMR SOLUTION STRUCTURE OF A COMPLEX OF CALMODULIN WITH A BINDING PEPTIDE OF THE CA2+-PUMP  1ckk: CALMODULIN/RAT CA2+/CALMODULIN DEPENDENT PROTEIN KINASE FRAGMENT  1cll: CALMODULIN STRUCTURE REFINED AT 1.7 ANGSTROMS RESOLUTION  1cm1: MOTIONS OF CALMODULIN-SINGLE-CONFORMER REFINEMENT  1cm4: MOTIONS OF CALMODULIN-FOUR-CONFORMER REFINEMENT  1cmf: NMR SOLUTION STRUCTURE OF APO CALMODULIN CARBOXY-TERMINAL DOMAIN  1cmg: NMR SOLUTION STRUCTURE OF CALCIUM-LOADED CALMODULIN CARBOXY-TERMINAL DOMAIN  1ctr: DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX  1deg: THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE  1dmo: CALMODULIN, NMR, 30 STRUCTURES  1f70: REFINED SOLUTION STRUCTURE OF CALMODULIN N-TERMINAL DOMAIN  1f71: REFINED SOLUTION STRUCTURE OF CALMODULIN C-TERMINAL DOMAIN  1fw4: CRYSTAL STRUCTURE OF E. COLI FRAGMENT TR2C FROM CALMODULIN TO 1.7 A RESOLUTION  1g4y: 1.60 A CRYSTAL STRUCTURE OF THE GATING DOMAIN FROM SMALL CONDUCTANCE POTASSIUM CHANNEL COMPLEXED WITH CALCIUM-CALMODULIN  1iq5: Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment  1iwq: Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin  1j7o: Solution structure of Calcium-calmodulin N-terminal domain  1j7p: Solution structure of Calcium calmodulin C-terminal domain  1k90: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP  1k93: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin  1l7z: Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide  1lin: CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:4 COMPLEX)  1lvc: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP  1mux: SOLUTION NMR STRUCTURE OF CALMODULIN/W-7 COMPLEX: THE BASIS OF DIVERSITY IN MOLECULAR RECOGNITION, 30 STRUCTURES  1mxe: Structure of the Complex of Calmodulin with the Target Sequence of CaMKI  1niw: Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin  1nwd: Solution Structure of Ca2+/Calmodulin bound to the C-terminal Domain of Petunia Glutamate Decarboxylase  1ooj: Structural genomics of Caenorhabditis elegans : Calmodulin  1pk0: Crystal Structure of the EF3-CaM complexed with PMEApp  1prw: Crystal structure of bovine brain Ca++ calmodulin in a compact form  1qiv: CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD), 1:2 COMPLEX  1qiw: CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD)  1qs7: The 1.8 angstrom structure of calmodulin rs20 peptide complex  1qtx: THE 1.65 ANGSTROM STRUCTURE OF CALMODULIN RS20 PEPTIDE COMPLEX  1qx5: Crystal structure of apoCalmodulin  1qx7: Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel  1s26: Structure of Anthrax Edema Factor-Calmodulin-alpha,beta-methyleneadenosine 5'-triphosphate Complex Reveals an Alternative Mode of ATP Binding to the Catalytic Site  1sk6: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate  1sw8: Solution structure of the N-terminal domain of Human N60D calmodulin refined with paramagnetism based strategy  1sy9: Structure of calmodulin complexed with a fragment of the olfactory CNG channel  1up5: CHICKEN CALMODULIN  1vrk: THE 1.9 ANGSTROM STRUCTURE OF E84K-CALMODULIN RS20 PEPTIDE COMPLEX  1wrz: Calmodulin complexed with a peptide from a human death-associated protein kinase  1x02: Solution structure of stereo array isotope labeled (SAIL) calmodulin  1xa5: Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid  1xfu: Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin  1xfv: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP  1xfw: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP)  1xfx: Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride  1xfy: Crystal structure of anthrax edema factor (EF) in complex with calmodulin  1xfz: Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride  1y0v: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate  1y6w: Trapped intermediate of calmodulin  1yr5: 1.7-A structure of calmodulin bound to a peptide from DAP kinase  1yrt: Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin  1yru: Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin and 1mM calcium chloride  1zot: crystal structure analysis of the CyaA/C-Cam with PMEAPP  1zuz: Calmodulin in complex with a mutant peptide from human DRP-1 kinase  2bbm: SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR  2bbn: SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR  2bcx: Crystal structure of calmodulin in complex with a ryanodine receptor peptide  2be6: 2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex  2bkh: MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2) CRYSTAL STRUCTURE  2bki: MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2-IQ) CRYSTAL STRUCTURE  2col: Crystal structure analysis of CyaA/C-Cam with Pyrophosphate  2dfs: 3-D structure of Myosin-V inhibited state  2f2o: Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode  2f2p: Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode  2f3y: Calmodulin/IQ domain complex  2f3z: Calmodulin/IQ-AA domain complex  2fot: Crystal structure of the complex between calmodulin and alphaII-spectrin  2hf5: The structure and function of a novel two-site calcium-binding fragment of calmodulin  2ix7: STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V  3cln: STRUCTURE OF CALMODULIN REFINED AT 2.2 ANGSTROMS RESOLUTION  4cln: STRUCTURE OF A RECOMBINANT CALMODULIN FROM DROSOPHILA MELANOGASTER REFINED AT 2.2-ANGSTROMS RESOLUTION

External links

• UniProt entry