Butamirate
Clinical data | |
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AHFS/Drugs.com | International Drug Names |
ATC code | R05DB13 (WHO) |
Pharmacokinetic data | |
Protein binding | 98% |
Biological half-life | 6 hours |
Excretion | 90% renal |
Identifiers | |
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CAS Number | 18109-80-3 |
PubChem (CID) | 28892 |
ChemSpider | 26873 |
UNII | M75MZG2236 |
KEGG | D07594 |
ChEMBL | CHEMBL1332546 |
ECHA InfoCard | 100.038.172 |
Chemical and physical data | |
Formula | C18H29NO3 |
Molar mass | 307.428 g/mol |
3D model (Jmol) | Interactive image |
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Butamirate (or brospamin) is a cough suppressant.[1]
A study found it to bind to the cough center in the medulla oblongata, more specifically the dextromethorphan-binding site in guinea pig brain with high affinity.[2]
As a 2-(2-diethylaminoethoxy)ethyl ester, it is chemically related to oxeladin and pentoxyverine, which are in the same class. (Oxeladin has an additional ethyl group in its carboxylic acid, pentoxyverine has both ethyl groups of oxeladin replaced by one cyclopentyl in the same place.)
References
- ↑ Germouty, J.; Weibel, M. A. (1990). "Clinical comparison of butamirate citrate with a codeine-based antitussive agent". Revue medicale de la Suisse romande. 110 (11): 983–986. PMID 1980027.
- ↑ Klein, M.; Musacchio, J. M. (1989). "High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents". The Journal of Pharmacology and Experimental Therapeutics. 251 (1): 207–215. PMID 2477524.
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