Boromycin

Boromycin
Clinical data
ATC code none
Legal status
Legal status
Identifiers
CAS Number 34524-20-4 YesY
PubChem (CID) 6436027
ChemSpider 16735705 YesY
UNII 49559OZO07 N
ChEBI CHEBI:77880 N
Chemical and physical data
Formula C45H74BNO15
Molar mass 879.878 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Boromycin is a bacteriocidal polyether-macrolide antibiotic. It was initially isolated from the Streptomyces strain Streptomyces antibioticus, and is notable for being the first natural product found to contain the element boron. It is effective against most Gram-positive bacteria, but is ineffective against Gram-negative bacteria. Boromycin kills bacteria by negatively affecting the cytoplasmic membrane, resulting in the loss of potassium ions from the cell.

Anti-HIV activity

Recent studies have suggested that boromycin has potent anti-HIV activity. It was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in vitro. The mechanism of action for the anti-HIV activity of boromycin is suggested to involve interfering with the later stage of HIV infection, and possibly the maturation step for the replication of HIV.

References

This article is issued from Wikipedia - version of the 5/25/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.