Beta-thromboglobulin

Beta-thromboglobulin (β-thromboglobulin, also called Pro-Platelet basic protein) is a protein that is stored in alpha-granules of platelets and released in large amounts after platelet activation.[1]

It is a type of Chemokine (C-X-C motif) ligand 7.[2]

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It is a chemoattractant, strongly for fibroblasts and weakly for neutrophils. It is a stimulator of mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis in human fibroblasts.[1]

Beta-Thromboglobulin also affects megakaryocyte maturation, and thus helps in regulating platelet production.[1]

Clinical use

Levels of Beta-Thromboglobulin is used to index platelet activation. It is measured by ELISA in blood plasma or urine, and often in conjunction with Platelet factor 4)[1]

It is elevated in diabetes mellitus.[3]

References

  1. 1 2 3 4 Cytokines & Cells Online Pathfinder Encyclopaedia --> Beta-Thromboglobulin Retrieved on August 17, 2009
  2. ↑ Pillai MM, Iwata M, Awaya N, Graf L, Torok-Storb B (May 2006). "Monocyte-derived CXCL7 peptides in the marrow microenvironment". Blood. 107 (9): 3520–6. doi:10.1182/blood-2005-10-4285. PMC 1895768Freely accessible. PMID 16391012.
  3. ↑ Page 121 in: Sterne, Jonathan; Kirkwood, Betty R. (2003). Essential medical statistics. Oxford: Blackwell Science. ISBN 0-86542-871-9.
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