Beta-carotene 3-hydroxylase
| Beta-carotene 3-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.129 | ||||||||
| CAS number | 133425-64-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Beta-carotene 3-hydroxylase (EC 1.14.13.129, beta-carotene 3,3'-monooxygenase, CrtZ) is an enzyme with systematic name beta-carotene,NADH:oxygen 3-oxidoreductase .[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- beta-carotene + 2 NADH + 2 H+ + 2 O2 zeaxanthin + 2 NAD+ + 2 H2O (overall reaction)
- (1a) beta-carotene + NADH + H+ + O2 beta-cryptoxanthin + NAD+ + H2O
- (1b) beta-cryptoxanthin + NADH + H+ + O2 zeaxanthin + NAD+ + H2O
Beta-carotene 3-hydroxylase requires ferredoxin and Fe(II).
References
- ↑ Sun, Z.; Gantt, E.; Cunningham, F.X. Jr. (1996). "Cloning and functional analysis of the β-carotene hydroxylase of Arabidopsis thaliana". J. Biol. Chem. 271 (40): 24349–24352. doi:10.1074/jbc.271.40.24349. PMID 8798688.
- ↑ Fraser, P.D.; Miura, Y.; Misawa, N. (1997). "In vitro characterization of astaxanthin biosynthetic enzymes". J. Biol. Chem. 272 (10): 6128–6135. doi:10.1074/jbc.272.10.6128. PMID 9045623.
- ↑ Fraser, P.D.; Shimada, H.; Misawa, N. (1998). "Enzymic confirmation of reactions involved in routes to astaxanthin formation, elucidated using a direct substrate in vitro assay". Eur. J. Biochem. 252 (2): 229–236. doi:10.1046/j.1432-1327.1998.2520229.x. PMID 9523693.
- ↑ Bouvier, F.; Keller, Y.; d'Harlingue, A.; Camara, B. (1998). "Xanthophyll biosynthesis: molecular and functional characterization of carotenoid hydroxylases from pepper fruits (Capsicum annuum L.)". Biochim. Biophys. Acta. 1391 (3): 320–328. doi:10.1016/s0005-2760(98)00029-0. PMID 9555077.
- ↑ Linden, H. (1999). "Carotenoid hydroxylase from Haematococcus pluvialis: cDNA sequence, regulation and functional complementation". Biochim. Biophys. Acta. 1446 (3): 203–212. doi:10.1016/s0167-4781(99)00088-3. PMID 10524195.
- ↑ Zhu, C.; Yamamura, S.; Nishihara, M.; Koiwa, H.; Sandmann, G. (2003). "cDNAs for the synthesis of cyclic carotenoids in petals of Gentiana lutea and their regulation during flower development". Biochim. Biophys. Acta. 1625 (3): 305–308. doi:10.1016/s0167-4781(03)00017-4. PMID 12591618.
- ↑ Choi, S.K.; Matsuda, S.; Hoshino, T.; Peng, X.; Misawa, N. (2006). "Characterization of bacterial β-carotene 3,3′-hydroxylases, CrtZ, and P450 in astaxanthin biosynthetic pathway and adonirubin production by gene combination in Escherichia coli". Appl. Microbiol. Biotechnol. 72 (6): 1238–1246. doi:10.1007/s00253-006-0426-2. PMID 16614859.
External links
- Beta-carotene 3-hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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