Bart De Strooper
Bart De Strooper is a Belgian molecular biologist and professor at the Katholieke Universiteit Leuven (Leuven, Belgium). He is co-director of the VIB Center for the Biology of Disease at KU Leuven.
Bart De Strooper obtained an MD at the Katholieke Universiteit Leuven in 1985 and a PhD in 1992. He did a Postdoc at the EMBL in Heidelberg Germany in 1994. He is VIB Group leader since 1999, and Scientific Director, Department of Molecular and Developmental Genetics since 2007.
His research interest are the secretases which are proteases which cleave the amyloid peptide from the amyloid precursor protein (APP). The amyloid peptide is the main constituent of the plaques in the brain in Alzheimer's Disease. Together with Christian Haass he received the Potamkin Prize in 2002.
References
- De Strooper, B.; Saftig, P.; Craessaerts, K.; Vanderstichele, H.; Guhde, G.; Annaert, W.; von Figura, K.; Van Leuven, F. (1998). "Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein". Nature. 391 (6665): 387–90. doi:10.1038/34910. PMID 9450754.
- De Strooper, B.; Kopan, R.; Annaert, W.; Cupers, P.; Saftig, P.; Craessaerts, K.; Mumm, J. S.; Schroeter, E. H.; Schrijvers, V.; Wolfe, M. S.; Ray, W. J.; Goate, A. (1999). "A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain". Nature. 398 (6727): 518–22. doi:10.1038/19083. PMID 10206645.