Chlortetracycline

Chlortetracycline
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Routes of
administration
Oral, IV, topical
ATC code A01AB21 (WHO) D06AA02 (WHO) J01AA03 (WHO) S01AA02 (WHO) QG51AA08 (WHO) QJ51AA03 (WHO)
Pharmacokinetic data
Bioavailability 30%
Protein binding 50 to 55%
Metabolism Hepatic (75%)
Biological half-life 5.6 to 9 hours
Excretion Renal and biliary
Identifiers
CAS Number 57-62-5 YesY
PubChem (CID) 54675777
ChemSpider 10469370 YesY
UNII WCK1KIQ23Q YesY
KEGG D07689 YesY
ChEMBL CHEMBL456066 N
E number E702 (antibiotics)
ECHA InfoCard 100.000.310
Chemical and physical data
Formula C22H23ClN2O8
Molar mass 478.88 g/mol
3D model (Jmol) Interactive image
Melting point 168 to 169 °C (334 to 336 °F)
 NYesY (what is this?)  (verify)

Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 by Benjamin Minge Duggar working at Lederle Laboratories under the supervision of Yellapragada Subbarow. Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.[1] The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.

In veterinary medicine, chlortetracycline is commonly used to treat conjunctivitis in cats.[2]

References

  1. Jukes, Thomas H. Some historical notes on chlortetracycline. Reviews of Infectious Diseases 7(5):702-707 (1985).
  2. Merck Veterinary Manual.


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