Chlortetracycline
Clinical data | |
---|---|
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Routes of administration | Oral, IV, topical |
ATC code | A01AB21 (WHO) D06AA02 (WHO) J01AA03 (WHO) S01AA02 (WHO) QG51AA08 (WHO) QJ51AA03 (WHO) |
Pharmacokinetic data | |
Bioavailability | 30% |
Protein binding | 50 to 55% |
Metabolism | Hepatic (75%) |
Biological half-life | 5.6 to 9 hours |
Excretion | Renal and biliary |
Identifiers | |
| |
CAS Number | 57-62-5 |
PubChem (CID) | 54675777 |
ChemSpider | 10469370 |
UNII | WCK1KIQ23Q |
KEGG | D07689 |
ChEMBL | CHEMBL456066 |
E number | E702 (antibiotics) |
ECHA InfoCard | 100.000.310 |
Chemical and physical data | |
Formula | C22H23ClN2O8 |
Molar mass | 478.88 g/mol |
3D model (Jmol) | Interactive image |
Melting point | 168 to 169 °C (334 to 336 °F) |
| |
| |
(what is this?) (verify) |
Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 by Benjamin Minge Duggar working at Lederle Laboratories under the supervision of Yellapragada Subbarow. Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.[1] The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.
In veterinary medicine, chlortetracycline is commonly used to treat conjunctivitis in cats.[2]
References
- ↑ Jukes, Thomas H. Some historical notes on chlortetracycline. Reviews of Infectious Diseases 7(5):702-707 (1985).
- ↑ Merck Veterinary Manual.
This article is issued from Wikipedia - version of the 10/26/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.