Arrestin beta 1

ARRB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IV8
Identifiers
Aliases	ARRB1, ARB1, ARR1, Arrestin beta 1
External IDs	MGI: 99473 HomoloGene: 2981 GeneCards: ARRB1
Gene ontology Molecular function • ion channel binding • GTPase activator activity • histone acetyltransferase activity • transcription regulatory region DNA binding • estrogen receptor binding • enzyme inhibitor activity • insulin-like growth factor receptor binding • transcription factor binding • follicle-stimulating hormone receptor binding • mitogen-activated protein kinase kinase binding • clathrin adaptor activity • protein phosphorylated amino acid binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • protein binding • AP-2 adaptor complex binding • alpha-1B adrenergic receptor binding • V2 vasopressin receptor binding • phosphoprotein binding • angiotensin receptor binding • ubiquitin protein ligase binding • alpha-1A adrenergic receptor binding Cellular component • cytoplasm • cytosol • postsynaptic membrane • membrane • nucleus • cell projection • dendritic spine • heterotrimeric G-protein complex • chromatin • plasma membrane • intracellular • nucleoplasm • clathrin-coated pit • pseudopodium • postsynaptic density • Golgi membrane • cytoplasmic, membrane-bounded vesicle • lysosomal membrane • basolateral plasma membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle Biological process • positive regulation of Rho protein signal transduction • positive regulation of protein phosphorylation • regulation of G-protein coupled receptor protein signaling pathway • positive regulation of receptor internalization • transcription from RNA polymerase II promoter • stress fiber assembly • follicle-stimulating hormone signaling pathway • platelet activation • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of GTPase activity • positive regulation of ERK1 and ERK2 cascade • positive regulation of insulin secretion involved in cellular response to glucose stimulus • proteasome-mediated ubiquitin-dependent protein catabolic process • phototransduction • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of peptidyl-serine phosphorylation • negative regulation of interleukin-8 production • protein ubiquitination • protein transport • negative regulation of protein phosphorylation • G-protein coupled receptor signaling pathway • positive regulation of smooth muscle cell apoptotic process • activation of MAPK activity • positive regulation of histone H4 acetylation • transport • positive regulation of protein binding • negative regulation of NF-kappaB transcription factor activity • positive regulation of protein ubiquitination • G-protein coupled receptor internalization • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • endocytosis • negative regulation of interleukin-6 production • positive regulation of histone acetylation • negative regulation of protein ubiquitination • negative regulation of ERK1 and ERK2 cascade • negative regulation of signal transduction • positive regulation of transcription from RNA polymerase II promoter • signal transduction • positive regulation of GTPase activity • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	408	109689
Ensembl	ENSG00000137486	ENSMUSG00000018909
UniProt	P49407	Q8BWG8
RefSeq (mRNA)	NM_004041 NM_020251	NM_177231 NM_178220
RefSeq (protein)	NP_004032.2 NP_064647.1	NP_796205.1 NP_835738.1
Location (UCSC)	Chr 11: 75.26 – 75.35 Mb	Chr 7: 99.54 – 99.61 Mb
PubMed search	[1]	[2]
Wikidata

Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.^[3][4]

Function

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.^[4] Beta-arrestin might also play a role as scaffold protein in the GPCR pathways.

Interactions

Arrestin beta 1 has been shown to interact with

• Arf6,^[5]
• PTHLH,^[6]
• DVL2^[7]
• Mdm2,^[8][9]
• OPRD1,^[10]
• PSCD2,^[5] and
• RALGDS.^[11]

References

Further reading

• Shukla, A. K.; Westfield, G. H.; Xiao, K; Reis, R. I.; Huang, L. Y.; Tripathi-Shukla, P; Qian, J; Li, S; Blanc, A; Oleskie, A. N.; Dosey, A. M.; Su, M; Liang, C. R.; Gu, L. L.; Shan, J. M.; Chen, X; Hanna, R; Choi, M; Yao, X. J.; Klink, B. U.; Kahsai, A. W.; Sidhu, S. S.; Koide, S; Penczek, P. A.; Kossiakoff, A. A.; Woods Jr, V. L.; Kobilka, B. K.; Skiniotis, G; Lefkowitz, R. J. (2014). "Visualization of arrestin recruitment by a G-protein-coupled receptor". Nature. 512: 218–22. doi:10.1038/nature13430. PMID 25043026. 

PDB gallery
1g4m: CRYSTAL STRUCTURE OF BOVINE BETA-ARRESTIN 1  1g4r: CRYSTAL STRUCTURE OF BOVINE BETA-ARRESTIN 1  1jsy: Crystal structure of bovine arrestin-2  1zsh: Crystal structure of bovine arrestin-2 in complex with inositol hexakisphosphate (IP6)