Allan Maxam

Allan Maxam
Born October 28, 1942 (1942-10-28) (age 74)
Doctoral advisor Walter Gilbert
Known for DNA sequencing

Allan Maxam (born October 28, 1942) is one of the pioneers of molecular genetics. He was one of the contributors to develop a DNA sequencing method at Harvard University, while working as a student in the laboratory of Walter Gilbert.[1][2]

Walter Gilbert and Allan Maxam developed a DNA sequencing method which combined chemicals that cut DNA only at specific bases with radioactive labeling and electrophoresis through acrylamde gels to determine the sequence of long DNA segments.[3]

References

  1. Maxam, A M; Gilbert, W (1977), "A new method for sequencing DNA.", Proc. Natl. Acad. Sci. U.S.A. (published Feb 1977), 74 (2), pp. 560–4, doi:10.1073/pnas.74.2.560, PMC 392330Freely accessible, PMID 265521
  2. DNA SEQUENCING AND GENE STRUCTURE, Walter Gilbert Nobel lecture, 8 December, 1980
  3. Maxam AM, Gilbert W, Sequencing end-labeled DNA with base-specific chemical cleavages, Methods Enzymol. 1980;65(1):499-560

See also


This article is issued from Wikipedia - version of the 10/23/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.