Abieta-7,13-dien-18-al dehydrogenase

Abieta-7,13-dien-18-al dehydrogenase (EC 1.2.1.74, abietadienal dehydrogenase (ambiguous)) is an enzyme with systematic name abieta-7,13-dien-18-al:NAD⁺ oxidoreductase.^[1]^[2] This enzyme catalyses the following chemical reaction

abieta-7,13-dien-18-al + H₂O + NAD⁺

\rightleftharpoons

abieta-7,13-dien-18-oate + NADH + H⁺

This enzyme catalyses the last step of the pathway of abietic acid biosynthesis in Abies grandis.

References

↑ Funk, C.; Croteau, R. (1994). "Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis". Arch. Biochem. Biophys. 308 (1): 258–266. doi:10.1006/abbi.1994.1036. PMID 8311462.
↑ Funk, C.; Lewinsohn, E.; Vogel, B.S.; Steele, C.L.; Croteau, R. (1994). "Regulation of oleoresinosis in grand fir (Abies grandis) (coordinate induction of monoterpene and diterpene cyclases and two cytochrome P450-dependent diterpenoid hydroxylases by stem wounding)". Plant Physiol. 106 (3): 999–1005. doi:10.1104/pp.106.3.999. PMC 159624. PMID 12232380.

Aldehyde/oxo oxidoreductases (EC 1.2)

1.2.1: NAD or NADP	Aldehyde dehydrogenase Acetaldehyde dehydrogenase Long-chain-aldehyde dehydrogenase

1.2.2: cytochrome	Formate dehydrogenase (cytochrome)

1.2.3: oxygen	Aldehyde oxidase

1.2.4: disulfide	Oxoglutarate dehydrogenase complex Pyruvate dehydrogenase Branched-chain alpha-keto acid dehydrogenase complex BCKDHA BCKDHB DBT DLD

1.2.7: iron-sulfur protein	Pyruvate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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