Asialoglycoprotein receptor

asialoglycoprotein receptor 1
Identifiers
Symbol	ASGR1
Entrez	432
HUGO	742
OMIM	108360
RefSeq	NM_001671
UniProt	P07306
Other data
Locus	Chr. 17 p13-p11

asialoglycoprotein receptor 2
Identifiers
Symbol	ASGR2
Entrez	433
HUGO	743
OMIM	108361
RefSeq	NM_080914
UniProt	P07307
Other data
Locus	Chr. 17 p

The asialoglycoprotein receptors are lectins which bind asialoglycoprotein, glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are located on liver cells, remove the target glycoproteins from circulation. The asialoglycoprotein receptor has been demonstrated to have high expression on the surface of hepatocytes and several human carcinoma cell lines. Lactobionic acid has been used as a targeting moiety for drug delivery to cells expressing asialoglycoprotein receptors.

External links

Asialoglycoprotein receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

Protein: lectins

Animal

C-type lectins	Asialoglycoprotein receptor KLRD1 Collectin Mannan-binding lectin Mannose receptor proteochondroitin sulfate Aggrecan Versican Brevican Neurocan

Other	Calnexin Calreticulin CD22 CD33 Galectin Myelin-associated glycoprotein N-Acetylglucosamine receptor Selectin Sialoadhesin

Plant

Membrane proteins, receptors: cell surface receptors

G protein–coupled receptor

Class A	Eicosanoid receptor (Prostaglandin receptor) Protease-activated receptor Neurotransmitter receptor Purinergic receptor Biogenic amine receptor Olfactory receptor

Class B	Secretin receptor

Class C	Metabotropic glutamate receptor

Class D	Pheromone receptor

Class E	cAMP receptor

Class F	Frizzled/smoothened

Ligand-gated ion channel

Purinergic receptor

Enzyme-linked receptor

Other/ungrouped

This article is issued from Wikipedia - version of the 5/25/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.