AKAP12

AKAP12
Identifiers
Aliases AKAP12, AKAP250, SSeCKS, A-kinase anchoring protein 12
External IDs MGI: 1932576 HomoloGene: 3740 GeneCards: AKAP12
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

9590

83397

Ensembl

ENSG00000131016

ENSMUSG00000038587

UniProt

Q02952

Q9WTQ5

RefSeq (mRNA)

NM_005100
NM_144497

NM_031185

RefSeq (protein)

NP_005091.2
NP_653080.1

NP_112462.1

Location (UCSC) Chr 6: 151.24 – 151.36 Mb Chr 10: 4.27 – 4.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

A-kinase anchor protein 12 is an enzyme that in humans is encoded by the AKAP12 gene.[3][4]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinase A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[4]

Interactions

AKAP12 has been shown to interact with Beta-2 adrenergic receptor.[5][6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Nauert JB, Klauck TM, Langeberg LK, Scott JD (Mar 1997). "Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein". Curr. Biol. 7 (1): 52–62. doi:10.1016/S0960-9822(06)00027-3. PMID 9000000.
  4. 1 2 "Entrez Gene: AKAP12 A kinase (PRKA) anchor protein (gravin) 12".
  5. Fan G, Shumay E, Wang H, Malbon CC (Jun 2001). "The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization". J. Biol. Chem. 276 (26): 24005–14. doi:10.1074/jbc.M011199200. PMID 11309381.
  6. Shih M, Lin F, Scott JD, Wang HY, Malbon CC (Jan 1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin". J. Biol. Chem. 274 (3): 1588–95. doi:10.1074/jbc.274.3.1588. PMID 9880537.

External links

Further reading


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