AANAT (gene)

AANAT

Identifiers

AANAT, DSPS, SNAT, aralkylamine N-acetyltransferase

External IDs

MGI: 1328365 HomoloGene: 31013 GeneCards: AANAT

Gene ontology
Molecular function	• transferase activity • N-acetyltransferase activity • 14-3-3 protein binding • arylamine N-acetyltransferase activity • protein binding • transferase activity, transferring acyl groups • aralkylamine N-acetyltransferase activity
Cellular component	• cytoplasm • cytosol • perinuclear region of cytoplasm
Biological process	• melatonin biosynthetic process • response to cytokine • response to organic cyclic compound • photoperiodism • response to light stimulus • response to copper ion • rhythmic process • response to corticosterone • response to zinc ion • indolalkylamine biosynthetic process • response to calcium ion • response to insulin • response to prostaglandin E • circadian rhythm • N-terminal protein amino acid acetylation • response to cAMP • cellular response to cAMP
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


15


11298

Ensembl


ENSG00000129673


ENSMUSG00000020804

UniProt


Q16613


O88816

RefSeq (mRNA)


NM_001088 NM_001166579


NM_009591

RefSeq (protein)


NP_001079.1 NP_001160051.1


NP_033721.1

Location (UCSC)

Chr 17: 76.45 – 76.47 Mb

Chr 11: 116.59 – 116.6 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

AANAT is a gene that encodes an enzyme aralkylamine N-acetyltransferase.^[3] It is the key regulator of day-night cycle (circadian rhythm). It is found in all animals. In humans it is present on chromosome 17, in chimpanzees chromosome 17, in mouse and sheep chromosome 11, in rat chromosome 10, and in chicken chromosome 18.^[4]

Function

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation.^[3]

Clinical significance

This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.^[3]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 3 "Entrez Gene: Aralkylamine N-acetyltransferase".
↑ "AANAT". NCBI. Retrieved 2 November 2014.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

Human AANAT genome location and AANAT gene details page in the UCSC Genome Browser.

This article is issued from Wikipedia - version of the 11/28/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.