4-oxoproline reductase

In enzymology, a 4-oxoproline reductase (EC 1.1.1.104) is an enzyme that catalyzes the chemical reaction

4-hydroxy-L-proline + NAD⁺ 4-oxoproline + NADH + H⁺

Thus, the two substrates of this enzyme are 4-hydroxy-L-proline and NAD⁺, whereas its 3 products are 4-oxoproline, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 4-hydroxy-L-proline:NAD⁺ oxidoreductase. This enzyme is also called hydroxy-L-proline oxidase. This enzyme participates in arginine and proline metabolism.

References

• Smith TE; Mitoma C (1962). "Partial purification and some properties of 4-ketoproline reductase". J. Biol. Chem. 237: 1177–1180. PMID 13914427.