1,4-Butanediol

1,4-Butanediol
Names
IUPAC name
Butane-1,4-diol
Other names
Tetramethylene glycol
Identifiers
110-63-4 YesY
3D model (Jmol) Interactive image
Interactive image
ChEMBL ChEMBL171623 YesY
ChemSpider 13835209 YesY
DrugBank DB01955 YesY
ECHA InfoCard 100.003.443
EC Number 203-786-5
RTECS number EK0525000
UNII 7XOO2LE6G3 YesY
Properties[1][2]
C4H10O2
Molar mass 90.12 g·mol−1
Density 1.0171 g/cm3 (20 °C)
Melting point 20.1 °C (68.2 °F; 293.2 K)
Boiling point 235 °C (455 °F; 508 K)
Miscible
Solubility in ethanol Soluble
1.4460 (20 °C)
Hazards[2][3]
GHS pictograms
GHS signal word WARNING
H302
P264, P270, P301+312, P330, P501
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oil Health code 1: Exposure would cause irritation but only minor residual injury. E.g., turpentine Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
1
1
0
Flash point 121 °C (250 °F; 394 K)(open cup)
350 °C (662 °F; 623 K)
Related compounds
Related butanediols
 1,2-Butanediol
1,3-Butanediol
2,3-Butanediol
Related compounds
 Succinaldehyde
Succinic acid
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references

1,4-Butanediol, colloquially known as BD, is the organic compound with the formula HOCH2CH2CH2CH2OH. This colorless viscous liquid is derived from butane by placement of alcohol groups at each end of the chain. It is one of many stable isomers of butanediol.

Synthesis

In its industrial synthesis, acetylene reacts with two equivalents of formaldehyde to form 1,4-butynediol. This type of acetylene-based process is illustrative of what is known as "Reppe chemistry", after German chemist Walter Reppe. Hydrogenation of 1,4-butynediol gives 1,4-butanediol. This route is used by BASF and Ashland/ISP.

LyondellBasell manufactures 1,4-butanediol in a multi-step process without the use of acetylene. First, propylene oxide is converted to allyl alcohol. The allyl alcohol is then hydroformylated to 4-hydroxybutyraldehyde. Hydrogenation of this aldehyde yields 1,4-butanediol.[4]

It is also manufactured on an industrial scale from maleic anhydride in the Davy process, which is first converted to the methyl maleate ester, then hydrogenated. Other routes are from butadiene, allyl acetate and succinic acid.[5]

A biological route to BDO has been commerciallized that uses a genetically modified organism.[6] The biosynthesis proceeds via 4-hydroxybutyrate.

Industrial use

1,4-Butanediol is used industrially as a solvent and in the manufacture of some types of plastics, elastic fibers and polyurethanes. In organic chemistry, 1,4-butanediol is used for the synthesis of γ-butyrolactone (GBL). In the presence of phosphoric acid and high temperature, it dehydrates to the important solvent tetrahydrofuran.[7] At about 200 °C in the presence of soluble ruthenium catalysts, the diol undergoes dehydrogenation to form butyrolactone.[8]

World production of 1,4-butanediol was claimed to be about one million metric tons per year and market price is about 2,000 USD (1,600 EUR) per ton (2005). In 2013, worldwide production was claimed to be billions of lbs (consistent with approximately one million metric tons).[9]

Almost half of it is dehydrated to tetrahydrofuran to make fibers such as Spandex.[10] The largest producer is BASF.[11]

Health effects and use as a drug

FDA warning against products containing GHB and its prodrugs, such as 1,4-butanediol.

1,4-Butanediol is also used as a recreational drug known by some users as "One Comma Four", "Liquid Fantasy", "One Four Bee" or "One Four B-D-O". It exerts effects similar to γ-hydroxybutyrate (GHB), which is a metabolic product of 1,4-butanediol.[12][13] When mixed with other drugs, misuse of 1,4-butanediol has resulted in addiction and death.[14]

Pharmacokinetics

1,4-Butanediol is converted into GHB by the enzymes alcohol dehydrogenase and aldehyde dehydrogenase and differing levels of these enzymes may account for differences in effects and side effects between users.[15] While co-administration of ethanol and GHB already poses serious risks, co-administration of ethanol with 1,4-butanediol will interact considerably and has many other potential risks. This is because the same enzymes that are responsible for metabolizing alcohol also metabolize 1,4-butanediol so there is a strong chance of a dangerous drug interaction.[15][16] Emergency room patients who overdose on both ethanol and 1,4-butanediol often present with symptoms of alcohol intoxication initially and as the ethanol is metabolized the 1,4-butanediol is then able to better compete for the enzyme and a second period of intoxication ensues as the 1,4-butanediol is converted into GHB.[15]

Metabolic pathway of 1,4-butanediol, γ-butyrolactone and γ-hydroxybutyric acid (GHB).

Pharmacodynamics

1,4-Butanediol seems to have two types of pharmacological actions. The major psychoactive effects of 1,4-butanediol are because it is metabolized into GHB; however there is a study suggesting that 1,4-butanediol may have potential alcohol-like pharmacological effects that are not due to this conversion.[16] One should note that the study arrived at this conclusion based on the finding that 1,4-butanediol co-administered with ethanol led to potentiation of some of the behavioral effects of ethanol. However, potentiation of ethanol's effects may simply be caused by competition for the alcohol dehydrogenase and acetaldehyde dehydrogenase enzymes with co-administered 1,4-butanediol. The shared metabolic rate-limiting steps thus leads to slowed metabolism and clearance for both compounds including ethanol's known toxic metabolite acetaldehyde.

Another study found no effect following intracerebroventricular injection in rats of 1,4-butanediol.[17] This contradicts the hypothesis that 1,4-butanediol having inherent alcohol-like pharmacological effects.

Like GHB, 1,4-butanediol is only safe in small amounts. Adverse effects in higher doses include, nausea, vomiting, dizziness, sedation, vertigo, and potentially death if ingested in large amounts. Anxiolytic effects are diminished and side effects increased when used in combination with alcohol.

Legality

While 1,4-butanediol is not currently scheduled federally in the United States, it is illegal to distribute it over the internet except in certain cases.[18] Additionally, a number of states have classified 1,4-butanediol as a controlled substance. Individuals have been prosecuted for 1,4-butanediol under the Federal Analog Act as substantially similar to GHB.[19] A federal case in New York in 2002 ruled that 1,4-butanediol could not be considered an analog of GHB under federal law,[20] but that decision was later overturned by the Second Circuit.[21] However, a Federal District Court in Chicago ruled that 1,4-butanediol could not be considered an analog of GHB under federal law, and the Seventh Circuit Court of Appeals upheld that ruling.[22] In the United Kingdom, 1,4-butanediol was scheduled in December 2009 (along with another GHB precursor, gamma-butyrolactone) as a Class C controlled substance. In Germany, the drug is not explicitly illegal, but might also be treated as illegal if used as a drug. It is controlled as a Schedule VI precursor in Canada.

2007 contamination of Bindeez toy

See also: Bindeez

A toy called "Bindeez" ("Aqua Dots" in North America) was recalled by the distributor in November 2007 because of the presence of 1,4-butanediol. The toy consists of small beads that stick to each other by sprinkling water. 1,4-Butanediol was detected by GC-MS.[23] The production plant seems to have intended to cut costs by replacing less toxic 1,5-pentanediol with 1,4-butanediol. ChemNet China listed the price of 1,4 butanediol at between about US$1,350–2,800 per metric ton, while the price for 1,5-pentanediol is about US$9,700 per metric ton.[24]

References

  1. ↑ Weast, Robert C., ed. (1981). CRC Handbook of Chemistry and Physics (62nd ed.). Boca Raton, FL: CRC Press. p. C-190. ISBN 0-8493-0462-8..
  2. 1 2 1,4-Butanediol, International Chemical Safety Card 1104, Geneva: International Programme on Chemical Safety, March 1999
  3. ↑ HSNO Chemical Classification Information Database, New Zealand Environmental Risk Management Authority, retrieved 2009-08-29
  4. ↑ ACS Patent Watch - December 7, 2009, The American Chemical Society
  5. ↑ Ashford's Dictionary of Industrial Chemicals (3rd ed.), 2011, p. 1517, ISBN 978-0-9522674-3-0
  6. ↑ http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8067214.PN.&OS=PN/8067214&RS=PN/8067214
  7. ↑ Karas., L.; Piel, W. J., "Ethers", Kirk-Othmer Encyclopedia of Chemical Technology, New York: John Wiley, ISBN 9780471238966
  8. ↑ Zhao, Jing; Hartwig, John F. (2005), "Acceptorless, neat, ruthenium-catalyzed dehydrogenative cyclization of diols to lactones", Organometallics, 24 (10): 2441–46, doi:10.1021/om048983m
  9. ↑ "Commercial-scale production of bio-based BDO announced", Chemical Engineering, Feb 2013, archived from the original on 2015-03-25, retrieved 2013-02-21
  10. ↑ "Butanediol (price and demand in market)", Chemical Week, 12 April 2006, retrieved 2008-11-21
  11. ↑ "Malaysia: New 1,4-butanediol plant used below capacity", Asian Textile Business, April 2004, retrieved 2008-11-21
  12. ↑ Satta, Rosalba; Dimitrijevic, Nikola; Manev, Hari (2003), "Drosophila metabolize 1,4-butanediol into γ-hydroxybutyric acid in vivo", Eur. J. Pharmacol., 473 (2–3): 149–52, doi:10.1016/S0014-2999(03)01993-9, PMID 12892832
  13. ↑ Carai, Maurio A. M.; Colombo, Giancarlo; Reali, Roberta; Serra, Salvatore; Mocci, Ignazia; Castelli, M. Paola; Cignarella, Giorgio; Gessa, Gian Luigi (2002), "Central effects of 1,4-butanediol are mediated by GABAB receptors via its conversion into γ-hydroxybutyric acid", Eur. J. Pharmacol., 441 (3): 157–63, doi:10.1016/S0014-2999(02)01502-9, PMID 12063087
  14. ↑ Zvosec, Deborah L.; Smith, Stephan W.; McCutcheon, J. Rod; Spillane, Joe; Hall, Bradley J.; Peacock, Elizabeth A. (2001), "Adverse events, including death, associated with the use of 1,4-butanediol", New Engl. J. Med., 344 (2): 87–94, doi:10.1056/NEJM200101113440202, PMID 11150358
  15. 1 2 3 Benzer, Theodore I.; Cameron, Scott; Russi, Christopher Scott (8 January 2007), Toxicity, Gamma-Hydroxybutyrate, eMedicine, retrieved 2009-08-29
  16. 1 2 Poldrugo, Flavio; Snead, O. Carter, III (1984), "1,4-butanediol, γ-hydroxybutyric acid and ethanol: Relationships and interactions", Neuropharmacology, 59 (23): 109–13, doi:10.1016/0028-3908(84)90226-0, PMID 6717752
  17. ↑ Carter, LP; Koek, W; France, CP (2006), "Lack of effects of GHB precursors GBL and 1,4-BD following i.c.v. Administration in rats", The European Journal of Neuroscience, 24 (9): 2595–600, doi:10.1111/j.1460-9568.2006.05146.x, PMID 17100847
  18. ↑ "21 U.S. Code § 841 - Prohibited acts A". LII / Legal Information Institute. Retrieved 2016-08-02.
  19. ↑ USA v Washam (2002) 312 F.3d 926, 930; http://cases.justia.com/us-court-of-appeals/F3/312/926/608696/
  20. ↑ http://www.erowid.org/chemicals/14b/14b_law1.shtml
  21. ↑ United States v. Roberts, 363 F.3d 118 (2d Cir. 2004); https://scholar.google.com/scholar_case?case=13457043198797192346&q=363+F.3d+118&hl=en&as_sdt=6,39
  22. ↑ United States v. Turcotte, 405 F.3d 515 (7th Cir. 2005) "With specific regard to 1,4 Butanediol, the jury has returned a special verdict which states that 1,4-Butanediol is not a Schedule I Narcotic Drug Controlled Substance analogue, because 1,4-Butanediol's chemical structure is not significantly similar to the chemical structure of GHB.
  23. ↑ Wang, Linda (9 November 2007), "Industrial Chemical Sullies Popular Children's Toy", Chemical & Engineering News, retrieved 2009-08-11
  24. ↑ "US mother says her son began to stumble and vomit after eating Chinese-made toy, now recalled", Boston Herald, Associated Press, 8 November 2007

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